It is widely acknowledged that Micro-, Small and Medium-sized Enterprises (MSMEs) play a crucial role in the tourism and hospitality sectors across the globe in terms of contribution to local and national economies, supporting livelihoods and key to achieving the Sustainable Development Goals (SDGs). The United Nations Micro-, Small and Medium-sized Enterprises Day is an opportunity to celebrate entrepreneurs, leaders and changemakers – and this year with a special attention to women and youth entrepreneurs. MSMEs in the tourism and hospitality sectors is often where one can find the best practices and implementation of cutting edge innovations when it comes down to environmental and social sustainability as well as conservation, restoration and regeneration approaches. Two MSME leaders and members of The Long Run - Preferred by Nature (https://www.thelongrun.org/), are discussing how hospitality MSMEs advance sustainability while also learning from crises and share the barriers and opportunities for women entrepreneurship while sharing also tips and best practices!